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These genes regulate essential cellular processes, including mitochondrial function, autophagy, lysosomal activity, proteasomal degradation, cellular stress responses, inflammation, and synaptic homeostasis, all of which contribute to the pathogenesis of the disease [24]

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The shifted peak contained both RBD-Fc and hACE2 ( Supplementary Figure 3C ), indicating the formation of stable complexes between these RBD-Fc mutants and hACE2 respectively