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It is modified with: An arginine substitution at position 3 (hence “Arg3”) An extended amino acid chain that lengthens its half-life from a matter of minutes to around 20–30 hours This modification prevents IGF-1 LR3 from binding to IGF-binding proteins (IGFBPs) as readily, allowing it to remain active in the bloodstream longer and exert more potent effects

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This can also be used for inflammatory conditions and autoimmune disease such as cystic fibrosis, HIV or AIDS, or Lyme disease

1 LR3 protein has been specifically engineered for higher biological potency and is used in the maintenance of human pluripotent stem cells.