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1.2 Adverse Outcome Pathways and Aggregate Exposure Pathways The AOP offers a structured framework to illustrate the underlying biological mechanisms, connecting a molecular initiating event (MIE) through a series of key events (KE) up to the occurrence of an adverse outcome (AO) at the organism or population level (36)

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thermophilus Recombinants The sod plasmids pKLH161-pKLH165, pKLH167-pKLH168, and pKLH295-pKLH306 as well as the control plasmid pKLH32 (without sod ) were transformed into S-3 by electroporation