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Cytokines such as IL-6, IL-10, and TGF-β produced by tumor cells in the TME hinder the activation of NK cells ( via a CCL1, CCL5-induced chemokine cascade that is disseminated by tumor cells, and CCL3 produced by TAMs is retained in the primary tumor ( Figure 3
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It should be considered that the actual antipsychotic for schizophrenia therapy is a combination of xanomeline and trospium, with the latter to prevent peripheral adverse events of muscarinic agonism [334]
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