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However, in the context of persistent exposure and chronic inflammation in COPD, reduced mitochondrial biogenesis, imbalance in fusion/fission, and insufficient or excessive activation of mitophagy transform mitochondrial injury from a transient stress into a chronic cumulative process (19)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Toth M.J., Poehlman E.T., Matthews D.E., Tchernof A., MacCoss M.J