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The GLU hypothesis of schizophrenia 4 grew out of the observation that phencyclidine, a drug of abuse that is a potent NMDA antagonist (50-fold stronger than ketamine), can trigger in healthy individuals a severe psychosis indistinguishable from schizophrenia, with positive and negative symptoms, cognitive impairment, thought disorder, catatonia, and agitation
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Post-surgical patients interested in supporting their body's recovery process may also be candidates, though as always, any peptide exploration should involve close coordination with the treating provider team
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