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Dihexa is reported to be active at picomolar concentrations in synaptogenesis assays—approximately 10,000–10,000,000-fold more potent than BDNF (brain-derived neurotrophic factor) in some in vitro measures, though this comparison involves different assay conditions and should not be taken as a direct clinical equivalence claim
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Warning signs that warrant medical attention include spreading redness, pus, prolonged pain, or fever (possible infection), and new dark or light patches (post-inflammatory pigment change), which is a particular consideration for medium-to-deep skin tones
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