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Tissue-resident macrophages maintain their populations primarily through self-renewal under steady-state conditions, whereas monocyte-derived macrophages are recruited and contribute to inflammation or injury (Guan et al., 2025)

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It is also worth noting that a large cluster of long heparan polymers on the cell surface could be associated with multiple dimeric c-MET/HGF complexes and in principle induce the higher-order oligomerization of c-METs, and potentially lead to the formation of even larger biomolecular condensates on the cell membrane