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Although this hydrogen bond only involves the ribose moiety of the mRNA residue, it is plausible to speculate that the mRNA residue 3′-adjacent to the AUA codon could influence AUA decoding, because the base of the mRNA residue can engage in stacking interaction with the AUA codon

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The response curves show that most participants were still losing weight at week 68, suggesting that longer treatment durations might produce even greater reductions

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