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Drug synergism was measured using the Loewe model with Combenefit software (Cancer Research UK Cambridge Institute), and the combination index was calculated using CompuSyn software (ComboSyn) ( 3 Results 3.1 CB-839 treatment inhibits glutathione synthesis and the conversion of glutamine to glutamate in CLL cell lines Initially, we investigated CB-839’s functional inhibition of GLS-1 ( Figures 1A, B )
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COA Testing Parameters Identity Verification – HPLC and Mass Spectrometry confirm molecular structure Purity Analysis – HPLC quantification, typically ≥98% Concentration Accuracy – Verified dosing levels Molecular Weight – Mass spectrometry confirmation Endotoxin Screening – LAL assay, Bacterial Endotoxins Test Particulate Matter: Complies with USP Particulate Matter specifications FOR RESEARCH USE ONLY
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