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Due to their short diffusion lengths and rapid scavenging, these radicals exert their effects within nanometer-to-submicrometer microdomains, making receptor-proximal membranes and specific enzyme complexes privileged initial targets [101–103] (Fig
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This finding raises the possibility of using PD-1 expression levels of immune cells as a biomarker of immune checkpoint blockade responsiveness ( Dendritic cell counts within TDLN of patients with NSCLC are reduced when compared to NDLN (46)
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