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There was no significant cytotoxicity irrespective of glucose supplementation with metformin ≤2.5mM
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Sympathetic activation and hypothalamic–pituitary–adrenal (HPA) axis dysregulation have also been linked to the development and exacerbation of several risk factors for T2DM, such as insulin resistance, impaired glucose tolerance, oxidative stress, and proinflammatory states [72]
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