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This process can make multidrug-resistant cancer cells more responsive to chemotherapy by enhancing chromatin relaxation, mainly through the acetylation of histone H4K16
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1,2,3,4 In this process, the bone marrow (BM), as the central tissue/organ of hematopoiesis, undergoes marked alterations in hematopoietic dynamics, manifested by skewed myeloid differentiation and increased neutrophil production
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