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Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways | Nature Chemical Biology
found that amplifying hypoxia-inducible factor (HIF) signaling pathways triggered ferroptosis in chemotherapy-resistant GBM cells and suppressed tumor growth in animal models, suggesting that inducing ferroptosis by targeting HIF-α could improve GBM treatment
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As a result, neither peptide can currently be considered superior to the other based on high-quality clinical evidence
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