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Similar content being viewed by others Introduction Adenylate-forming enzymes are a mechanistic superfamily of structurally diverse enzymes that are found across all three domains of life and play critical roles in a wide range of biological processes, including protein synthesis [1, 2] and posttranslational modifications [3,4,5,6], nucleoside/nucleotide [7,8,9], amino acid [10, 11] and fatty acid metabolism [12,13,14], and natural product biosynthesis [15,16,17,18,19,20,21,22,23,24]

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Based on insights from non-septic AKI models, the transmembrane protein CD36 can promote FSP1 ubiquitination and degradation, thereby exacerbating tubular injury (84)