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But there is a clinical profile that keeps appearing in this research: High-fit indicators: Diagnosed or suspected IBD, IBS, or chronic gut inflammation Gut symptoms co-occurring with anxiety, depression, or cognitive fatigue History of NSAID overuse with documented gut damage Post-infectious gut dysfunction (post-COVID gut dysbiosis, SIBO) Chronic stress with concurrent gut and mood symptoms Failed standard interventions for either gut or neurological symptoms Metabolic dysfunction with elevated systemic inflammation markers This overlap isn't random