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Additionally, the release of heme and iron from excess unpaired alpha-globin chains increases the oxidant susceptibility of thalassemia red blood cells (RBCs), initiating self-amplifying redox reactions that further oxidize hemoglobin, accelerate RBC destruction, and deplete cellular reducing potential, such as glutathione (GSH) [31]

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FORMULATION:NORMAL STRENGTH

Traditional kava is made by grinding fresh or dried kava root, mixing it with water or coconut milk, and straining it into a communal bowl