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EBV miR-BART9-3p, along with its homologous miR-141-3p, targets and inhibits the expression of the host transcription factor FOXO3 during BCR cross-linking, thereby reducing its inhibitory effect on BCR-induced viral lytic activation ( in vivo ( 4 Host factors determine the progress of EBV reactivation Epstein-Barr virus reactivation involves the crosstalk of multiple signaling pathways, and the processes are also regulated by various host factors (Figure 3 and Table 3)