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To determine if FoxP3 reconstitution alone in Gclc- deficient Tregs could rescue their suppressive capacity, we transduced Foxp3 cre - Gclc fl/fl Tregs with control or Foxp3 -expressing retrovirus and subjected transduced CD90.1 + iTregs to in vitro suppression assays
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It inhibits the activation of the transcription factor NF-ΞΊB, reducing the production of pro-inflammatory cytokines (IL-1Ξ², TNF-Ξ±, IL-6) and inflammatory mediators (PGE2, NO)
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