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study ( In addition, CSD, a hallmark of migraine pathogenesis, can cause oxidative stress ( On a molecular basis, the TRPA1 (Transient receptor potential ankyrin subtype 1) ion channels in nociceptors allow the release of calcitonin gene-related peptide (CGRP) from dural afferents upon activation, mediating neurogenic inflammation, and migraine behavioral picture in animal models ( Neuroinflammation Neurogenic inflammation describes the phenomenon of arteriolar vasodilation, plasma protein extravasation, and degranulation of mast cells, caused by the release of potent vasoactive neuropeptides (mainly CGRP, substance P, and neurokinin A) from activated peripheral nociceptive nerve terminals

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BPC-157 may also be appropriate for selected patients with gut irritation, inflammatory gut symptoms, gastritis-type symptoms, reflux-type irritation, or medication-related GI irritation when it is part of a broader gut-health plan