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Pathology attributed to advanced glycation endproducts can also occur through binding of these compounds to the receptor for advanced glycation endproducts (RAGE) that is expressed in Schwann and endothelial cells (36, 37)
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Phosphorylation of IκBα on serines 32 and 36 by the IKK complex (primarily IKKβ) targets it for ubiquitination
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