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It can participate in one-carbon metabolism through serine hydroxymethyltransferase (SHMT) to support nucleotide synthesis, and can also serve as a component of glutathione (GSH) in maintaining cellular redox homeostasis ( Threonine (Thr) can likewise enter the one-carbon metabolic network and can be converted by threonine dehydrogenase (TDH) into intermediates such as acetyl-CoA, thereby providing a link between energy metabolism and epigenetic regulation ( Overall, the effects of Ser/Gly/Thr metabolism on macrophage polarization are mainly mediated by changes in one-carbon metabolic flux, methyl donor availability, and redox homeostasis, and the resulting outcome is often manifested as “threshold regulation” of inflammatory transcriptional programs and alterations in phenotypic stability