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Bifidobacterium lactis IDCC 4301, instead, inhibits cell differentiation and lipid accumulation by suppressing the expression of adipogenic enzymes in 3T3-L1 cells, a standard model for studying the formation of body fat and then in high-fat diet-fed mice model [123]
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Extended Follow‐Up Durations : As most current studies are limited to relatively short durations (e.g., 8–24 weeks), future trials might benefit from extended follow‐up periods (e.g., ≥ 12 months) in order to more reliably assess sustained therapeutic effects and the potential for disease modification [125, 126]
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