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As these molecules are vital for life, metabolic reactions either focus on making these molecules during the construction of cells and tissues, or on breaking them down and using them to obtain energy, by their digestion

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Notably, the recognition of limited or partial EndoMT does not necessarily conflict with its potential functional relevance in PA stiffening, but simply suggests that this relevance may potentially relate more to the release of proliferative, hypertrophic, and profibrotic signals—i.e., mediators of processes that will ultimately promote PA stiffness—by partial EndoMT cells rather than to the actual generation of significant mesenchymal cell mass via this mechanism