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FBS is a rich source of iron and protein-complexed iron, which increases in concentration throughout gestation (Kakuta et al
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Mitochondrial-derived ROS and mtDNA, acting as DAMPs, activate the NLRP3 inflammasome, prompting immune cells to shift toward glycolysis to maintain their function ( The metabolites generated during metabolic reprogramming, including lactate and ROS, further impair local mitochondrial function, potentially exacerbating the energy deficit (142)
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