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Liposomal Glutathione Helps to Mitigate Mycobacterium tuberculosis Infection in the Lungs
(1) simple disulfide exchange with GSSG granted that GSSG is sufficiently concentrated (2GSH/GSSG is ~1), (2) S − is oxidized by H 2 O 2 generating a sulfenic acid (SOH) which, due to its very low pKa, can ionize and rapidly react with reduced glutathione (GSH), and (3) S − forms a thiyl radical which then interacts with GSH forming a thiyl radical glutathionyl intermediate which then interacts with O 2 to form PSSG (Mailloux et al., 2013a)
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doi: 10.1089/jmf.2017.0141
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