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DDI prediction was considered acceptable when the simulated ratios fell within the 0.80–1.25 range of the observed clinical values ( 2.4 PBPK model application 2.4.1 S-CIT as a victim drug: simulating DDI with four CYP2C19 inhibitors in young and older adults The validated PBPK models were applied to predict the extent of DDI between S-CIT and four CYP2C19 inhibitors (omeprazole, esomeprazole, fluconazole, and fluoxetine) in both older and young adult populations