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Limitations The sensitivity of the breath test used to assess the presence of SIBO has some limitations, although it is still the best approach to testing without invasive testing, such as gastrointestinal aspirates
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The porosity of the mucus hydrogel, the speed of MCC and the constantly evolving strategies used by pathogens to breach the mucus barrier all contribute to the effectiveness of the mucosal barrier in preventing epithelial cellular toxicities and infections (Box 2)
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