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The advent of MALDI, together with advances in MS instrumentation, improving specificity, sensitivity, speed, sampling, and automated computer data acquisition/deconvolution, established MALDI-based MS as an essential tool for label-free detection of intact biomolecules ( e.g
reversed-phase-chromatography
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Denmark provides an excellent example of how this can be done ( Reference Rasmussen, Carle and Jorgensen 33 )
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