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It can be concluded the metal-chelating ability of curcumin, driven by its unique chemical structure, plays a crucial role in neuroprotection by modulating enzyme activity, reducing oxidative stress and inflammation, inhibiting toxic protein aggregation, and alleviating metal-induced apoptosis, thereby offering a promising therapeutic strategy for NDs
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For oral supplementation in individuals with adequate absorption capacity, serum B12 levels typically begin rising within one to two weeks of starting treatment
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