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Specifically, Ca 2+ binds to and activates calmodulin, activating NFATc1b (a master transcription factor required for OC differentiation) and promoting OC differentiation (161)

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The cytoprotective (reduced reactive oxygen species and reduced cell senescence) effects of ergothioneine on endothelial cells exposed to hyperglycaemic conditions have been shown to be dependent on sirtuin 1 and sirtuin 6 activities and their cellular targets (Reference D’Onofrio, Servillo and Giovane89) , which notably include NF- κ B, the aforementioned transcriptional regulator of SLC22A4 (Reference Maeda, Hirayama and Kobayashi63)