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Pernicious Anaemia: When Your Body Can't Absorb Vitamin B12 Properly

GPX1 deficiency leads to GSH accumulation and an increase in the GSH/GSSG ratio, inducing S-glutathionylation at Cys463 and Cys333 of SHP-2 and sustained activation of c-ros oncogene 1, stimulating VSMC proliferation and migration, and promoting vascular remodeling and endothelialization [182]

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Beyond its production by enterochromaffin cells (ECCs), 5-HT is generated through tryptophan metabolism by Bacteroides, Lactococcus, and Klebsiella sp ecies , while its reuptake via the serotonin transporter (SERT) is inhibited by Escherichia coli (Esmaili et al., 2009)